Monte Carlo Simulation for the Evaluation of Measurement Uncertainty of Pharmaceutical Certified Reference Materials
نویسندگان
چکیده
O suplemento do Guia para a Expressão da Incerteza de Medição (GUM) publicado em 2008, o qual trata da propagação de distribuições, encoraja o uso do método de Monte Carlo (MC) para a estimativa de incerteza de medição. Este artigo descreve a aplicação deste método para estimativa da incerteza de medição do teor de ingredientes ativos farmacêuticos em dois novos materiais de referência certificados (MRC): metronidazol e captopril. Os resultados obtidos pelo método de Monte Carlo e pelo método tradicional (GUM) mostraram concordância considerando um valor crítico δ de 0,005 para metronidazol e 0,05 para captopril. Deste modo, o método de Monte Carlo validou os resultados obtidos pelo método tradicional (GUM) para a expressão do teor dos fármacos com no mínimo duas casas decimais.
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